| Acres | Sq miles | Rank | |
| Wrangell St Elias | 8323147.59 | 13,005 | 1 |
| Gates of the Arctic | 7523897.74 | 11,756 | 2 |
| Denali | 4740911.72 | 7,408 | 3 |
| Katmai | 3674529.68 | 5,741 | 4 |
| Death Valley | 3372401.96 | 5,269 | 5 |
| Glacier Bay | 3224840.31 | 5,039 | 6 |
| Lake Clark | 2619733.21 | 4,093 | 7 |
| Yellowstone | 2219790.71 | 3,468 | 8 |
| Kobuk Valley | 1750716.5 | 2,735 | 9 |
| Everglades | 1508537.9 | 2,357 | 10 |
| Grand Canyon | 1217403.32 | 1,902 | 11 |
| Glacier | 1013572.41 | 1,584 | 12 |
| Olympic | 922650.86 | 1,442 | 13 |
| Big Bend | 801163.21 | 1,252 | 14 |
| Joshua Tree | 789745.47 | 1,234 | 15 |
| Yosemite | 761266.19 | 1,189 | 16 |
| Kenai Fjords | 669982.99 | 1,047 | 17 |
| Isle Royale | 571790.11 | 893 | 18 |
| Great Smoky Mountains | 521490.13 | 815 | 19 |
| North Cascades | 504780.94 | 789 | 20 |
| Kings Canyon | 461901.2 | 722 | 21 |
| Sequoia | 404051.17 | 631 | 22 |
| Canyonlands | 337597.83 | 527 | 23 |
| Hawaii Volcanoes | 323431.38 | 505 | 24 |
| Grand Teton | 309994.66 | 484 | 25 |
| Rocky Mountain | 265828.41 | 415 | 26 |
| Channel Islands | 249561 | 390 | 27 |
| Badlands | 242755.94 | 379 | 28 |
| Mount Rainier | 235625 | 368 | 29 |
| Voyageurs | 218200.17 | 341 | 30 |
| Shenandoah | 199045.23 | 311 | 31 |
| Crater Lake | 183224.05 | 286 | 32 |
| Capitol Reef | 181971 | 284 | 33 |
| Biscayne | 172924.07 | 270 | 34 |
| Great Sand Dunes | 149027.9 | 233 | 35 |
| Zion | 146597.6 | 229 | 36 |
| Redwood | 112512.05 | 176 | 37 |
| Lassen Volcanic | 106372.36 | 166 | 38 |
| Petrified Forest | 93532.57 | 146 | 39 |
| Saguaro | 91439.71 | 143 | 40 |
| Guadalupe Mountains | 86415.97 | 135 | 41 |
| Great Basin | 77180 | 121 | 42 |
| Arches | 76518.98 | 120 | 43 |
| Theodore Roosevelt | 70446.89 | 110 | 44 |
| Dry Tortugas | 64701.22 | 101 | 45 |
| Mammoth Cave | 52830.19 | 83 | 46 |
| Mesa Verde | 52121.93 | 81 | 47 |
| Acadia | 47389.67 | 74 | 48 |
| Carlsbad Caverns | 46766.45 | 73 | 49 |
| Bryce Canyon | 35835.08 | 56 | 50 |
| Black Canyon of the Gunnison | 32950.03 | 51 | 51 |
| Cuyahoga Valley | 32860.73 | 51 | 52 |
| Haleakala | 29093.67 | 45 | 53 |
| Wind Cave | 28295.03 | 44 | 54 |
| Pinnacles | 26605.73 | 42 | 55 |
| Congaree | 26545.86 | 41 | 56 |
| Virgin Islands | 14688.87 | 23 | 57 |
| American Samoa | 9000 | 14 | 58 |
| Hot Springs | 5549.75 | 9 | 59 |
| Gateway Arch | 90.9 | 0.14 | 60 |